The RAAS Vasopressor
Synthetic angiotensin II for distributive shock refractory to high-dose catecholamines. High thrombosis risk requires strict anticoagulation prophylaxis.
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Mechanism: Synthetic Human Angiotensin II (AT1 agonist).
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Dosing: Initial: 20 ng/kg/min. Titrate: Up to 200 ng/kg/min based on MAP response.
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PK: Onset: Rapid. Half-life: Short.
indications
- Distributive Shock Refractory to High-Dose Catecholamines – Rescue therapy
evidence & efficacy
- ATHOS-3 Trial: Improved MAP, no mortality benefit.
cautions
- High Thrombosis Risk (Arterial/Venous) – Needs strict anticoagulation prophylaxis
- Expensive